Register at the forthcoming EFLM webinar “Hepatic fibrosis assessment using multiparametric biomarker tests”

Daniel Rajdl, Chair of the EFLM WG Distance Education and e-Learning informs about next webinars.  EFLM is happy to remind you that the attendance to the webinars is free of charge and that the recording of the lectures will be available afterwards on at the EFLM e-learning platform for those unable to attend.
Register at the forthcoming EFLM webinar!


Speaker: Ralf Lichtinghagen (DE)
Moderator: Merve Sibel Gungoren (TR)

Date: 2017-10-19 at h. 18.00 CET
time zone converter

ABSTRACT The stage of fibrosis is the most important single predictor of significant morbidity and mortality in chronic liver disease. The mechanisms leading to fibrosis and eventually cirrhosis are thought to be similar, irrespective of the underlying etiology. At cellular level, hepatic stellate cells (HSC) undergo a phenotypic switch usually addressed as transactivation. Activated HSC are regarded as the main source of extracellular matrix (ECM) in the fibrotic liver. Additional cell types namely fibroblasts and myofibroblasts may also contribute to ECM deposition. Despite the similarities in pathophysiology at cellular level, morphogenesis and histologic appearance of the fibrotic liver may differ according to the etiology. Liver biopsy remains the gold standard to evaluate liver fibrosis. Not least, one has to keep in mind that liver biopsy provides additional information like histological grading and etiology that may be overlooked when surrogate markers are used. Ideally, those tests should answer two questions. 1) What is the stage of fibrotic organ damage (i.e. the amount of deposited ECM and the disturbed balance of hepatic microarchitecture)? 2) What is the net balance between ECM deposition and degradation (i.e. the dynamics of ECM turnover)? The former serves to evaluate the prognosis and indicate therapy, while the latter might be used to control the efficacy of treatment with regard to disease progression. Many different parameters including standard clinical chemistry and parameters of matrix metabolism have been evaluated. In the last decade, markers were assembled to multiparametric scores. Here, we can distinguish scores assembled of standard clinical chemistry markers (e.g. aspartate aminotransferase-to-platelet ratio index, FibroTest, Forns’ index) from scores using circulating markers of hepatic matrix metabolism like hyaluronic acid (HA), tissue inhibitor of metalloproteinases-1 (TIMP-1), matrix metalloproteinase-2, propeptide of type III procollagen (PIIINP). In the webinar we will learn further details about the relevant complex scores, the clinical evaluation and current practical guidelines.
ABOUT THE SPEAKER Prof. Dr. Ralf Lichtinghagen obtained his doctorate at Ruhr University Bochum in the field of Neurobiochemistry in 1989. At the beginning of the 1990s he undertook further training at Hannover Medical University (Institute of Clinical Chemistry) to qualify as a European Specialist in Laboratory Medicine. He carried out different research projects on the pathophysiology of the extracellular matrix in chronic liver disease and acquired his authorization to teach Clinical Chemistry at the university in 2001. Today his main areas of research are molecular diagnostics and new biomarkers. In addition to his responsibilities in patient care and research he gives lectures in Clinical Chemistry / Laboratory Diagnostics and is the academic head of the Medical Laboratory Assistants School. Prof. Lichtinghagen is a chair of EFLM Education and Training Committee since 2016.
HOW TO REGISTER Registration at: https://elearning.eflm.eu/enrol/index.php?id=15

The participation is free of charge – The number of attendees is limited!


NEXT EFLM WEBINARS – Save the date in your calendar!

v  2017-11-14 – Harmonization of preanalytical phase in Europe
Speaker: Ana-Maria Simundic (HR)

v  2018-03-06 – Reliable estimates of biological variation – the way forward
Speaker: Aasne Karine Aarsand (NO)


RECORDED WEBINARS – See all our previous recorded webinars at https://elearning.eflm.eu/


European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)


Silvia Cattaneo – Via Carlo Farini, 81 – 20159 Milano – Italy

Tel: +39 389 5320051– e-mail: [email protected] – website: www.eflm.eu

Click to comment

Leave a Reply

Your email address will not be published. Required fields are marked *

Most Popular

Quis autem vel eum iure reprehenderit qui in ea voluptate velit esse quam nihil molestiae consequatur, vel illum qui dolorem?

Temporibus autem quibusdam et aut officiis debitis aut rerum necessitatibus saepe eveniet.

© 2006-2016 ACCLMU. Atlaskit.

To Top